Study: Biomarker Phenotyping of Pediatric Sepsis and Multiple Organ Failure 

Study Type: Observational
Study Period: September 2014 – January 2017
Enrollment: 410
Consent: Yes

Purpose:

Severe sepsis remains the leading killer of children worldwide. Most children dying from sepsis in the United States do so with Multiple Organ Failure (MOF). Sepsis induced MOF is a poorly understood syndrome for which treatment is directed to organ dysfunction rather than inflammation biomarker responses. In contrast, rheumatologic multiple system organ disease is considered to be a spectrum of inflammation pathobiology phenotypes that improve with use of specific therapies directed to normalizing inflammation biomarkers such as C-reactive protein (CRP) and Ferritin.

PHENOMS is a prospective observational cohort study to enroll children with severe sepsis to test the hypotheses that children with these phenotypes have; 1) increased mortality, 2) predisposing genotype and environmental risk factors, and 3) increased CRP and ferritin levels that correlate with clinical outcome. If patients’ clinical outcomes are related to a spectrum of inflammation pathobiology and increased systemic inflammation biomarkers, then this will inform a paradigm shift supporting future studies of the use of phenotype specific therapies.

Study Documents:

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